J Korean Assoc Oral Maxillofac Surg.  2016 Apr;42(2):111-114. 10.5125/jkaoms.2016.42.2.111.

Iron supplement tablet embedded in the oral cavity mimicking neoplasm: a case report

Affiliations
  • 1Department of Otorhinolaryngology, University of Siena, Siena, Italy. ishajacopo@hotmail.it

Abstract

The detection of foreign bodies in the upper-aerodigestive tract is a fairly frequent event and can occur in various areas and for various reasons. In rare cases, foreign bodies can simulate a neoplasia. We evaluated similar cases during emergency regimen with an oral cavity mucosal lesion, causing lockjaw, sore throat, dysphagia, and swelling of the submandibular and laterocervical region. Physical examination revealed an extensive mucosal ulceration in the floor of the mouth and the lateral surface of the tongue, comparable to oral cancer. During a second, more accurate assessment, a partially deteriorated iron supplement tablet was found embedded in a mucosal pocket. After removing the tablet, gradual normalization of the tissue was observed without any sequelae. This is one of the many reasons why it is advisable and useful in cases of oral lesions to collect a detailed medical history and to perform an accurate clinical evaluation, including inspection and palpation of the lesion, before proceeding to further diagnostic assessments, especially in elderly patients taking many medications. However unlikely, it is possible that difficulty in swallowing pills or tablets could generate tumorlike lesions.

Keyword

Mouth neoplasms; Iron deficiency anemia; Oral ulcer; Foreign bodies

MeSH Terms

Aged
Anemia, Iron-Deficiency
Deglutition
Deglutition Disorders
Emergencies
Foreign Bodies
Humans
Iron*
Mouth Neoplasms
Mouth*
Oral Ulcer
Palpation
Pharyngitis
Physical Examination
Tablets
Tongue
Trismus
Ulcer
Iron
Tablets

Figure

  • Fig. 1 First evaluation of the floor mouth lesion.

  • Fig. 2 Second evaluation of the lesion.

  • Fig. 3 Iron pill removed from the mucosal pocket.


Reference

1. Abraham SC, Yardley JH, Wu TT. Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity. Am J Surg Pathol. 1999; 23:1241–1247. PMID: 10524525.
2. Clarke BE, Kim ST. Iron-induced bronchial injury. Histopathology. 2002; 41:472–473. PMID: 12405917.
Article
3. Evrard C, Coffin O, Kaladji C, Brun J, Benard Y, Doumert J. Massive hemoptysis ten days after bronchial extraction of an accidentally inhaled tablet of ferrous sulfate. Ann Chir. 1991; 45:726–728. PMID: 1768033.
4. Godden DJ, Kerr KM, Watt SJ, Legge JS. Iron lung: bronchoscopic and pathological consequences of aspiration of ferrous sulphate. Thorax. 1991; 46:142–143. PMID: 2014497.
Article
5. Raos M, Kovac K, Dodig S. Bronchial impairment of main bronchus by aspiration of ferrous sulphate tablet. Lijec Vjesn. 2004; 126:194–196. PMID: 15754788.
6. Cimino-Mathews A, Broman JH, Westra WH, Illei PB. Iron pill-induced tumefactive mucosal injury of the hypopharynx. Am J Surg Pathol. 2010; 34:1720–1722. PMID: 20975344.
Article
7. Arora BK, Ruprecht A. Foreign body in tongue. Oral Surg Oral Med Oral Pathol. 1978; 45:823–825. PMID: 276800.
Article
8. Price C, Whitehead FI. Impression materials as foreign bodies. Br Dent J. 1972; 133:9–14. PMID: 4507102.
Article
9. Lin CJ, Su WF, Wang CH. A foreign body embedded in the mobile tongue masquerading as a neoplasm. Eur Arch Otorhinolaryngol. 2003; 260:277–279. PMID: 12750919.
Article
10. Sathish R, Suhas S, Gayathri G, Ravikumar G, Chandrashekar L, Omprakash TL. Embedded toothbrush foreign body in cheek: report of an unusual case. Eur Arch Paediatr Dent. 2011; 12:272–274. PMID: 21993069.
11. McKinney RV Jr, Brady GL, Singh BB. Metallic foreign body embedded in the cheek for 20 years. J Am Dent Assoc. 1981; 102:331–333. PMID: 7007469.
Article
12. Seikaly H, Rassekh CH. Oropharyngeal cancer. In : Bailey BJ, Johnson JT, Newlands SD, editors. Head and neck surgery: otolaryngology. 4th ed. Philadelphia: Lippincott Williams & Wilkins;2006. p. 1674–1690.
13. Kwon JI, Kim HW, Nam W, Cha IH, Kim HJ. Traumatic ulcerative granuloma misjudged as oral squamous cell carcinoma (SCC) on the buccal cheek: case report. J Korean Assoc Oral Maxillofac Surg. 2010; 36:217–220.
Article
14. Khan S, Agwani K, Bhargava P, Kumar SP. Adenoid cystic carcinoma presenting as an ulcer on the floor of the mouth: a rare case report. J Korean Assoc Oral Maxillofac Surg. 2014; 40:253–257. PMID: 25368840.
Article
15. Aruoma OI, Halliwell B. Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation? Biochem J. 1987; 241:273–278. PMID: 3032157.
Article
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