Korean J Anesthesiol.  1984 Jun;17(2):108-113.

Potentiation of Neuromuscular Blockade Produced by Combination of Pancuronium and d-Tubocurarine in Rabbits

• Yune GJ
• Kim IS

Abstract

Pancuronium 5 ug/kg, d-Tubocurarine 50 ug/kg and the combination of pancuronium and d-Tubocurarine were given to the rabbits of same genus under intravenous urethane anesthesia to determine the neuromuscular blocking effect of each drug. The rabbit was firmly fixed to a specially constructed metal board. The sciatic nerve was stimulated by means of train of four stimulation (4 volt, 6 msec, and 2 Hz). The evoked twitch and tracing of muscle of lower extremity was recorded contineously on a physiograph. When rabbit was stable, the drug for each group was given. The results are summarized as follows: 1) The pancuronium-d-Tubocurarine combination was significantly more potent for relaxation(p<0.005) than the effect of each of the individual drugs given alone. 2) The significant muscle relaxation of pancuronium-d-Tubocurarine combination appeared at 1 minute and most potent relaxation was observed 10 minutes after drug administration and at 25 minutes, 93% of this relaxation of pancuronium-d-Tubocurarine combination was recovered. 3) Blood pressure and pulse rate after pancuronium-d-Tubocurarine combination were not changed, but the respiration was depressed at 1 minute and the most significant depression was observed at 10 minutes after drug administration. The duration of the depression lasted about 30 minutes.

MeSH Terms

Anesthesia
Blood Pressure
Depression
Heart Rate
Lower Extremity
Muscle Relaxation
Neuromuscular Blockade*
Pancuronium*
Rabbits*
Relaxation
Respiration
Sciatic Nerve
Tubocurarine*
Urethane
Pancuronium
Tubocurarine
Urethane