The Effect of Bilateral Renal Pedicle Ligatin on the Action of Mivacurium in Rabbits

Kwon, Ou Kyoung; Lee, Yoon Ki

Abstract

Mivacurium, a new neuromuscular blocking agent, is known not to rely greatly on the renal function for its elimination, therefore, is recommended for the renal failure patient. In these studies, we investigated neuromuscular blocking action of mivacurium in case of bilateral ligation of renal pedicles to prevent the renal excretion and compared its action to that of pancuronium, which is mainly excreted by the kidney. Rabbits were divided into 4 groups: the mivacurium control group, the mivacurium group, the pancuronium control group, and the pancuronium group. Both renal arteries were ligated in the mivacurium group and the pancuronium group. After intravenous administration of mivacurium or pancuronium, the6neuromuscular blocking actions were observed. The results were as follows: 1.There was no significant difference in onset time between the mivacurium group(77+/-18.6 sec) and the mivacurium control group(100+/-36 sec). No significant difference between the pancuronium group(90+/-42 sec) and the pancuronium control group(101+/-43.8 sec), too. And no significant difference in change of onset time was found between the mivacurium group and the pancuronium group. 2.There was no significant difference in duration of action between the mivacurium group ,(664+/-85.2 sec) snd the mivacurium control group(500+/-134.4 sec). But significant difference was found between the pancuronium group(3453+/-1088.4 sec) and the pancuronium control group(1041+/-304.2 sec)(P<0.05). In the pancurounium group, the prolongation of duration of action was significantly greater than that in the mivacurium group(P<0.05). 3.There was no significant difference in recovery index between the mivacurium group (316+/-99.6 sec) and the mivacurium control group(230+/-66.3 seo). But there was significant difference between the pancuronium group(676+/-162.3 sec) and the pancuronium control group(274+/-92 sec)(P<0.05). The prolognation of recovery index in the pancuronium group was significantly greater than that in the mivacurium group(P<0.05).