Korean J Anesthesiol.  1985 Jun;18(2):156-160.

The Effect of Pretreated Pancronium with Subpsralytic Dose on Neuromuscular Blocking Onset

• Rha JY
• Kim SI
• Kim SY

Abstract

This study was undertaken to investigate the effect of subparalytic doses of pancuronium on the its onset time of action during induction before endotracheal intubation. The patients were composed of 20 healthy female and 20 male adults which were ASA class l and ll. At the time of intubation, the control group received a pancuronium 0.08mg/kg as a single bolus after a 2.5% thiopental sodium 5mg/kg injection, and the pretreatment group received subparalytic dose of pancuronium 0.015mg/kg before the thiopental sodium injection and then followed by pancuronium 0.08mg/kg 3 minutes later. The degree of neuromuscular transmission was measured using the train of four stimulation of the ulnar nerve repeated every 20 seconds, and the time was measured when the 1st twitch height(T1) was changed to 85%, 75%, 50% and 25%. The results were as follows; the onset time of neuromuscular blocking action was quicker in female patients than in male patients, and was significantly more rapid in both sexes in the pretreated group by 23.3 to 63.8% compared to the control group.

MeSH Terms

Adult
Female
Humans
Intubation
Intubation, Intratracheal
Male
Neuromuscular Blockade*
Pancuronium
Thiopental
Ulnar Nerve
Pancuronium
Thiopental