Korean J Anesthesiol.  1995 Feb;28(2):251-254. 10.4097/kjae.1995.28.2.251.

The Relationships between Onset Time and Recovery of Six Neuromuscular Blocking Drugs

• Kim SY
• Lee JC
• Kim SI
• Kim SC
• Park W

• KMID: 2239170
• DOI: http://doi.org/10.4097/kjae.1995.28.2.251

Abstract

There is an evidence that onset time and potency of the non-depolarizing neuromuscular blocking agents are related. However the relationship between onset time and the recovery has not been investigated yet. In this experiment, the onset times of six neuromuscular blocking agents have been compared with their recovery times. The neuromuscular transmission of mivacurium 0.15 mg/kg, atracurium 0.4 mg/kg, vecuronium 0.08 mg/kg, pipecuronium 0.08 mg/kg, pancuronium 0.1 mg/kg and succinylcholine 1 mg/kg were studied in 58 adult healthy patient (ASA I and II) during O2-N2O-isoflurane anesthesia using train-of-four stimulation with Relaxograph. It has been demonstrated that there is a close relationship between onset time and recovery in depolarizing neuromuscular blocking agent but not in non-depolarizing agents. Consequently, it is proposed that the relationships between the onset time and the recovery may hardly expected in clinical practice following systemic administration of non-depolarizing neuromuscular blocking agents.

Keyword

Neuromuscular blocking agents; Onset time; Recovery

MeSH Terms

Adult
Anesthesia
Atracurium
Humans
Neuromuscular Blockade*
Neuromuscular Blocking Agents
Pancuronium
Pipecuronium
Succinylcholine
Vecuronium Bromide
Atracurium
Neuromuscular Blocking Agents
Pancuronium
Pipecuronium
Succinylcholine
Vecuronium Bromide