Maxillofac Plast Reconstr Surg.  2016 Jul;38(7):26. 10.1186/s40902-016-0072-2.

Effect of hydroxyapatite on critical-sized defect

• Kim RW
• Kim JH
• Moon SY

• KMID: 2348899
• DOI: http://doi.org/10.1186/s40902-016-0072-2

Abstract

BACKGROUND
Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium.
METHODS
Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-Oss®, Geistlich Pharma Ag. Swiss, n = 11 defects), and (3) hydroxyapatite (Bongros®, Bio@ Inc., Seongnam, Korea, n = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis.
RESULTS
At 4 weeks after surgery, group 3 (42.90 ± 9.33 %) showed a significant difference (p < 0.05) compared to the control (30.50 ± 6.05 %) and group 2 (28.53 ± 8.62 %). At 8 weeks after surgery, group 1 (50.21 ± 6.23 %), group 2 (54.12 ± 10.54 %), and group 3 (50.92 ± 6.05 %) showed no significant difference in the new bone formation.
CONCLUSIONS
Bongros®-HA was thought to be the available material for regenerating the new bone formation.

Keyword

Bone graft; Hydroxyapatite; Artificial Bone; Xenograft; Bovine bone

MeSH Terms

Adult
Anesthesia, General
Animals
Autografts
Bone Regeneration
Carbon
Durapatite*
Gyeonggi-do
Heterografts
Humans
Korea
Male
Miners
Osteogenesis
Rats
Rats, Sprague-Dawley
Skull
Transplants
Carbon
Durapatite