J Korean Neurol Assoc.  2013 May;31(2):122-124.

Cisplatin-Induced Encephalopathy With Status Epilepticus

Affiliations
  • 1Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea. sejinmayo@ynu.ac.kr

Abstract

A 75-year old man with esophageal cancer presented with mental status change and seizures. He was under cisplatinand developed several times of generalized tonic-clonic seizures. The EEG (electroencephalography) showed triphasic waves and slowed background activity. He was diagnosed with status epilepticus and encephalopathy caused by cisplatin. He was treated with anticonvulsants and cisplatin was replaced by docetaxel. His mentality recovered completely and he had no more seizure. We conclude that physician using cisplatin should be aware of this rare complication.

Keyword

Cisplatin; Status epilepticus; Encephalopathy; Triphasic wave

MeSH Terms

Anticonvulsants
Cisplatin
Electroencephalography
Esophageal Neoplasms
Seizures
Status Epilepticus
Taxoids
Anticonvulsants
Cisplatin
Taxoids
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