J Korean Neurol Assoc.  1994 Sep;12(3):444-447.

Seasonal Variation of Fibrinolytic Activity

• Park JM
• Bang CO
• Lee TK
• Yoon SG
• Sung KB
• Oh GS
• Ahn MY
• Yang DH
• Shin HK

Abstract

BACKGROUND AND PURPOSE: Among the many factors having influence on seasonal incidence of thrombotic disease, we studied the seasonal variation of fibrinolytic activity, which might be thought to have influence on seasonal incidence of thrombotic disease. SUBJECT AND METHOD: Seasonal plasma tissue type plasminogen activator (t-PA) and euglobulin fibrinolytic activity (EFA) were measured in 18 male and 22 female normal volunteers during a year. RESULT: The level of t-PA was higher in winter than in spring (p<0.05), but was not significantly different in the other couples of four seasons. The level of EFA was higher in winter than in summer and in autumn (p<0.01), and was slightly higher in winter than in spring without significance. The level of EFA was higher in spring than in summer (p<0.05). There was no correlation between the level of t-PA and that of EFA in any of the seasons.
CONCLUSION
The fibrinolytic activity is higher at lower temperature than at higher temperature. Thus, it seems that a rise in fibrinolytic activity in cold weather counters certain changes which make a thrombotic event.

MeSH Terms

Family Characteristics
Female
Healthy Volunteers
Humans
Incidence
Male
Plasma
Seasons*
Tissue Plasminogen Activator
Weather
Tissue Plasminogen Activator