Tuberc Respir Dis.  1989 Jun;36(2):142-148. 10.4046/trd.1989.36.2.142.

Fibrinolytic Activity in Patients with Deep Vein Thrombosis

• KMID: 2528561
• DOI: http://doi.org/10.4046/trd.1989.36.2.142

Abstract

In order to evaluate the role of fibrinolytic activity in the generation of deep vèin thrombosis, we measured platelet count, bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time and fibrinogen concentration as coagulation profiles in 2 patients with deep vein thrombosis and 10 patients with combined pulmonary embolism and euglobulin lysis activity as fibrinolytic profile using fibrin plate methods in 6 patients with angiographically proven deep vein thrombosis before and after stimulation with venous occlusion by application with 60 mmHg for 5minutes The results s are as follows 1. Coagulation profiles were in normal ranges except one case in platelet number, one case in prothrombin time and three cases in fibrinogen concentration. 2. Euglobulin lysis time activity were lower in upper and lower extremities of the patient group compared to that of normal control group. 3. Accentuation of euglobulin lysis activity after stimulation was still lower in both extremities of the patients group compared to normal control. 4. Degree of accentuation of euglobulin lysis activity by stimulation was smaller in lower extremities compared to upper extremities in patients with deep vein thrombosis We conclude that the disturbance of fibrinolytic activity, especially in injured vessels, might be a factor to generate deep vein thrombosis with resulting pulmonary embolism.