J Korean Neurol Assoc.  1985 Dec;3(2):298-301.

A Case of Podophyllum Toxicity with Peripheral Polyneuropathy

• Lee SD
• Park YC
• Seo JK

Abstract

A case is reported ofsystemic toxicity by topically applied podophyllin. The patient was a 18-year-old girl who was treated at private gynecological clinic with 25% podophyllin resin for multiple vulval condyloma acuminata. Her apparent podophyllin toxicity begun 4 hours after topical application, presenting gastrointestinal symptoms such as nausea, vomiting, diarrhea and abdominal distension, followed by tingling sensation on hands and feet with motor weakness predominantly of distal limbs. She had never experienced disturbance of consciousness or other CNS symptoms. The symptoms of severe peripheral neuropathy had been improved by 72 days followup when she had mild impairement of vibration and position sense and mild dorsiflexion weakness of the feet.

MeSH Terms

Adolescent
Consciousness
Diarrhea
Extremities
Female
Follow-Up Studies
Foot
Hand
Humans
Nausea
Peripheral Nervous System Diseases
Podophyllin
Podophyllum*
Polyneuropathies*
Proprioception
Sensation
Vibration
Vomiting
Podophyllin