J Korean Med Assoc.  2013 Jun;56(6):533-540.

Clinical chemistry values in elderly Korean people: single institutional study

Affiliations
  • 1Department of Clinical Pathology, Kyungpook National University School of Medicine, Daegu, Korea. kesong@knu.ac.kr
  • 2Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea.
  • 3Department of Occupational Medicine, Kyungpook National University Hospital, Daegu, Korea.

Abstract

Laboratory values change with age and interpreting laboratory results from elderly people using the reference intervals for younger adults may not be appropriate. The authors investigated the distribution patterns of routine chemistry values from elderly people to determine whether current reference intervals are also valid for elderly people. A total of 1,215 persons older than 65 years and 1,827 healthy adults below 65 years of age were evaluated. Blood samples were collected after an overnight fast and analyzed for chemistry tests. Computing the central 95th percentile showed that the total protein, albumin, ALP, LD, creatinine, uric acid, triglyceride, HDL-cholesterol, and electrolytes of elderly people were within the standard reference intervals used in our laboratory. For AST and ALT, the upper range of the central 95th percentile in the elderly population was found to be outside the common reference interval. However, the central 90th percentile values of AST and ALT were compatible with the common reference intervals. GGT, BUN, total cholesterol, LDL-cholesterol, and glucose showed higher values than the upper limits of the reference intervals. For common clinical chemistry tests, the common reference values in general should be applicable to elderly people, even though some parameters showed wider distributions in the elderly.

Keyword

Clinical chemistry tests; Reference values; Aged

MeSH Terms

Adult
Aged
Chemistry, Clinical
Cholesterol
Clinical Chemistry Tests
Creatinine
Electrolytes
Glucose
Humans
Reference Values
Uric Acid
Cholesterol
Creatinine
Electrolytes
Glucose
Uric Acid

Figure

  • Figure 1 Central 95th percentile of clinical chemistry values in elderly people. ALP, alkaline phosphatase; RI, common reference interval; LD, lactate dehydrogenase; HDL, high-density lipoprotein. a)2.5 to 97.5 percentile in the age group I (65 years or above) of the research subjects. The upper and lower limits of the box are the 97.5 and 2.5 percentile and the horizontal bar is the median value (n=1,215).

  • Figure 2 Central 90th percentile, central 95th percentile of clinical chemistry values in elderly people. AST, aspartate transaminase; RI, common reference interval; GGT, gamma-glutamyl transpeptidase; BUN, blood urea nitrogen; T-Chol, total cholesterol; LDL, low-density lipoprotein; ALT, alanine transaminase. a)5.0 to 95.0 percentile in the age group I (65 years or above) of the research subjects. The upper and lower limits of the box are the 95.0 and 5.0 percentile and the horizontal bar is the median value. b)2.5 to 97.5 percentile in the age group I (65 years or above) of the research subjects. The upper and lower limits of the box are the 97.5 and 2.5 percentile and the horizontal bar is the median value (n=1,215).


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