J Korean Neuropsychiatr Assoc.  2006 Nov;45(6):598-603.

Modafinil Effect in Psychostimulant-Inapplicable Children with Attention Deficit Hyperactivity Disorder - Preliminary Study

• Yoo HK
• Kim JY
• Park S
• Jeon J
• Wang HR
• Kim BN
• Hong JP
• Kim SY
• Kim CY

Abstract

OBJECTIVES
This study was aimed to examine the efficacy and safety of modafinil in psychostimulant-inapplicable children with attention deficit hyperactivity disorder (ADHD) due to insufficient treatment response or intolerable adverse effects.
METHODS
Fifteen children (8.8+/-1.8 years, 14 boys, total IQ 107.22+/-13.4) were recruited for this study. ADHD was confirmed by K-SADS-PL. The efficacy was assessed by ADHD rating scale (ADHDRS), Conner's parental rating scale-revised (CPRS-R), ADHDRS school version, clinical global impression (CGI) and computerized neurocognitive function test. Mean dose of modafnil was 250. 0+/-103.3 mg.
RESULTS
Total score (p=0.012) and hyperactive/impulsive score (p=0.021) of ADHDRS for investigator, as well as CPRS-R score (p<0.01) and CGI-severity score (p<0.01) were significantly reduced after 39.2+/-8.7 days of modafinil administration. Response time of word color test was also significantly decreased after medication. Decreased appetite (2 subjects), insomnia (2 subjects), irritability (1 subject) and alopecia (1 subject) were observed during this study period.
CONCLUSION
Modafinil was effective and well-tolerated for the psychostimulant-inapplicable children with ADHD.

Keyword

ADHD; Modafinil

MeSH Terms

Alopecia
Appetite
Attention Deficit Disorder with Hyperactivity*
Child*
Humans
Parents
Reaction Time
Research Personnel
Sleep Initiation and Maintenance Disorders