J Korean Neuropsychiatr Assoc.
2005 Jan;44(1):116-119.
Diabetic Ketoacidosis in a Schizophrenic Patient Treated with Olanzapine: A Case Report
- Affiliations
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- 1Department of Psychiatry, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. cykim@amc.seoul.kr
- 2Department of Psychiatry, College of Medicine, University of Ulsan, Ulsan University Hospital, Ulsan, Korea.
Abstract
- The use of olanzapine has been associated with clinically significant hyperglycemia (exacerbation of existing diabetes, newonset type 2 diabetes and diabetic ketoacidosis). We report a case of diabetic ketoacidosis (DKA) in 30-year-old male patient with schizophrenia who was on olanzapine. When he was admitted to the hospital because of DKA, he had been taking olanzapine for 43 months. 14 months before the admission, his fasting and 2 hour postprandial serum glucose levels were normal. He had no personal and family history of diabetes mellitus. He had no risk factor for diabetes mellitus except for obesity (body mass index:39.2 kg/m2). He also had no precipitating factors for DKA such as infection or myocardial infarction. Periodic monitoring for changes in serum glucose levels in patients taking olanzapine may be needed.
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