J Korean Neuropsychiatr Assoc.
2000 Mar;39(2):373-380.
CAG Repeat Expansions in the Patients with Mood Disorder
- Affiliations
-
- 1Department of Psychiatry, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
- 2Center for Clincal Research, Samsung Biomedical Research Institute, Seoul, Korea.
- 3Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
- 4Department of Pediatrics, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
- 5Department of Pediatrics, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
Abstract
OBJECTIVES
The genetic facotrs have been suggested for the etiology of mood disorders but the mode of inheritance is complex. Increased severity and an earlier onset of the bipolar and major depressive disorder over generations within families(Anticipation) were reported. In order to test the hypothesis that trinucleotide repeat expansions underlie the genetic basis of Bipolar and major depressive disorders, we have analyzed the extent of CAG reapeats in genomic DNA from mood disorder patients.
METHODS
55 bipolar disorder, 67 major depressive disorder patients were recruited according to the DSM-III-R criteria. 89 normal controls were recruited from the medical personnel, students and the visitors to the health services center who had no history of psychiatric illness and show normal profile of MMPI. The genomic DNA of patients and controls was analyzed by use of the(CTG) 17 oligonucleotide and the repeat expansion detection(RED) method. The Mann-Whitney U test was used to compare the distribution of the number of CAG repeats among the groups.
RESULTS
when the bipolar disorder, major depressive disorder patients were compared with the control group, no significant differences were observed.
CONCLUSION
Our results do not support the hypothesis that expanding CAG repeats are causing the observed genetic anticipation in bipolar disorders and major depressive disorders.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Tardive Dyskinesia and CAG Repeat Expansions
- A Spinocerebellar Ataxia Type 6 Patient Caused by De Novo Expansion of Normal Range CAG Repeats
- Spinocerebellar Ataxia Type 6 in Two Korean Families
- A Study on CAG Repeat Polymorphisms of the Androgen Receptor in Korean Androgenetic Alopecia : Preliminary Report
- CAG-Expansion Haplotype Analysis in a Population with a Low Prevalence of Huntington's Disease
