Serum Immunoglobulin and Complement Levels in Schizophrenics

Shin, Soo A; Yun, Kyu Wol; Woo, Haing Won

Abstract

OBJECTIVE
The purpose of this study was to elucidate the biological correlates of schizophrenia by measuring the change of serum immuneglobulin and complement levels and investigating a relationship of clinical symptoms to serum immunoglobulin and complement levels in schizophrenics.
METHODS
The subjects were 27 inpatients, 13 men and 14 women, who met the diagnostic criteria for schizophrenia by Diagnostic and Statistical Manual of Mental Disorders IV(DSM-IV) and 24 normal controls, 8 men and 16 women. The serum immunoglobulin and complement levels of patients were measured at admission day and artier 2 weeks of treatment. Immunoglubulins and complement levels were obtained in serum using nephelometry. Positive and Negative Syndrome Scale(PANSS) were used to determine the clinical symptoms .
RESULTS
1) The serum IgG(p<.01) and IgM(p<.05) levels of schizophrenics measured at admission day were significantly lower than those of normal controls. 2) The serum C3 level significantly(p<.01) correlated with positive syndrome score. 3) The serum IgG levels of schizophrenics were significantly(p<.05) increased artier 2 weeks of treatment, especially in female schizophrenics. 4) The correlations of serum IgG, IgA, IgM, C3 and C4 to positive and negative syndrome scores of PANSS after treatment failed to get significant result.
CONCLUSION
It Is suggested that the Immune function of schizophrenics appears to be decreased when compared with normal controls and is slightly increased with clinical improvement. Significant correlation between C3 and positive syndrome score at admission suggests possibility of immunologic marker of acute schizophrenia.