J Korean Ophthalmol Soc.  2012 Mar;53(3):385-389.

Risk Factors of Graft Failure in Post-Keratoplasty Ocular Hypertension

  • 1Department of Ophthalmology and Visual Science, The Catholic University of Korea School of Medicine, Seoul, Korea. ckjoo@catholic.ac.kr


To assess the risk factors proceeding to graft failure in post-keratoplasty ocular hypertension patients.
In 35 eyes diagnosed with post-keratoplasty ocular hypertension (graft failure: 13 eyes; graft survival: 22 eyes), relationships between graft status at the observation time and pre-keratoplasty diagnosis, lens status, history of graft failure, donor size, difference between donor and recipient graft size, donor corneal endothelial cell count, post-keratoplasty intraocular pressure (after 1 week and maintenance intraocular pressure after surgery), and number of antiglaucomatic agents were investigated. The relative risks of each factor to induce graft failure were also evaluated.
Previous graft failure history, pre-existing pseudophakic bullous keratopathy and aphakia/pseudophakia showed statistically significant high probabilities of proceeding to graft failure (p < 0.05). In particular, the intraocular pressure 1 week after the graft was statistically higher (p < 0.05) in the graft failure group (24.31 +/- 8.82 mm Hg) than in the graft survival group (16.81 +/- 6.69 mm Hg).
Strict management of intraocular pressure in the early phase of penetrating keratoplasty could contribute to reducing graft failure in post-keratoplasty ocular hypertension patients.


Graft failure; Penetrating keratoplasty; Post-keratoplasty ocular hypertension

MeSH Terms

Endothelial Cells
Graft Survival
Intraocular Pressure
Keratoplasty, Penetrating
Ocular Hypertension
Risk Factors
Tissue Donors


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