J Korean Ophthalmol Soc.  1996 Jul;37(7):1095-1104.

A Clinical Study of Risk Factors of Graft Rejection for Penetrating Keratoplasty

• Myong YW
• Song SW
• Park CK

Abstract

Penetrating keratoplasty was performed on 185 eyes. We analyzed the relative risk about the high and low risk groups, sex, age, complication, neovascularization, and graft size. In 185 grafts, graft rejection was developed in 60 eyes(32.4%). In the low risk group, there was the most graft rejection in 17 keratoconus eyes(62.9%) and in the high risk group, in 18 eyes with vascularized corneal scar. Graft rejection was developed in 33 eyes(47.8%) of the high risk group and developed in 27 eyes(23.3%) of the low risk group. The high risk group increased the risk of graft rejection(Relative risk=3.022, P value=0.001). Graft rejection developed in 33 eyes(25%) with non-vascularization and in 27 eyes(52%) with neovascularization. Neovascularization increased the risk of graft rejection (Relative risk=3.273, P value<0.001). Loosening suture and neovascularization were the most common post-operative complications in 68 eyes, and in the graft size, the range from 7.5 to 7.9 mm, was the most rejection graft size. Sex, age, post-operative complication, and graft size were not maintained with association with graft rejection(P value >0.5). Mean preoperative visual acuity was 0.048 and mean postoperative visual acuity was 0.4. In the high risk group the mean postoperative corrected visual acuity was 0.25 and in the low risk group it was 0.5.

Keyword

graft rejection; high risk group; neovascularization

MeSH Terms

Cicatrix
Graft Rejection*
Keratoconus
Keratoplasty, Penetrating*
Risk Factors*
Sutures
Transplants*
Visual Acuity