J Korean Ophthalmol Soc.  2009 Nov;50(11):1661-1668.

Comparison of Macular Thickness Measurements Between Fourier-Domain and Time-Domain Optical Coherence Tomography in Normal Eyes and Eyes With Macular Diseases

• Ko BW
• Shin YW
• Lee JM
• Song Y
• Lee BR

Abstract

PURPOSE
To define and measure macular thickness and volume using Fourier domain OCT (FD OCT) and compare the values with Stratus OCT in normal eyes and eyes with macular disease.
METHODS
On the same day, macular thicknesses of the ETDRS 9 subfield and total macular volumes were measured in 35 eyes of 23 normal subjects and 19 diseased eyes of 24 patients with FD OCT and Stratus OCT. The macular cube scan protocol for FD OCT and the fast macular thickness map protocol for Stratus OCT were used to measure macular thicknesses.
RESULTS
Foveal thickness of the central subfield in FD OCT (251.49+/-79.45 micrometer) was thicker than the value of Stratus OCT (210.26+/-60.57 micrometer) (p<0.001) in all eyes. Total macular volume was 7.72+/-1.06 mm3 and 7.04+/-0.96 mm3 for FD OCT and Stratus OCT, respectively (p<0.001). Retina thickness of the ETDRS 9 subfields in FD OCT was thicker than the value obtained using Stratus OCT. In addition, foveal thickness differences were statistically significant in both the normal and diseased eye groups.
CONCLUSIONS
Macular thickness and total macular volume as measured by the FD OCT were larger than the values obtained using the Stratus OCT in both the normal and the diseased eye groups. The measuring algorithm of FD OCT defines the top of RPE as the outer retinal boundary, but Stratus OCT defines the outer retinal boundary as the IS/OS junction of the photoreceptor. Therefore, macular thicknesses of FD OCT are thicker than those of Stratus OCT. This difference should be considered when comparing the results of FD OCT with those of Stratus OCT.

Keyword

Fourier domain OCT; Macular thickness; Macular volume; Stratus OCT

MeSH Terms

Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Doxorubicin
Eye
Humans
Mitomycin
Retina
Retinaldehyde
Tomography, Optical Coherence
Antineoplastic Combined Chemotherapy Protocols
Cisplatin
Doxorubicin
Mitomycin
Retinaldehyde

Figure

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  Figure 1. Six radial scans of Stratus OCT (A) and macular cube scans of Fourier domain OCT (B).

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  Figure 2. Comparison of macular thickness measurements in 35 normal eyes (A) and 19 diseased eyes (B) between Fourier domain OCT (FD OCT) and Stratus OCT.

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  Figure 3. Fourier domain OCT (FD OCT) and Stratus OCT measurements in all patients (A), normal eyes (B), and diseased eyes (C) are graphed together.

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  Figure 4. Outer retinal boundary in Stratus OCT (arrow) and Fourier domain OCT (arrow head). The arrow indicates the inner segment/outer segment photoreceptor junction and the arrow head indicates the inner border of the retinal pigment epithelium.

Reference

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