J Korean Ophthalmol Soc.  2002 Aug;43(8):1510-1515.

The Effect of 5HT(3) Receptor Agonist on Intraocular Pressure and Pupil Diameter in Rabbits

• Lee EC
• Yoo JM
• Song JK

Abstract

PURPOSE: The effects of 5HT3 receptor agonist and antagonist on rabbit intraocular pressure (IOP) and pupil size were evaluated.
METHODS
A 5HT3 receptor agonist, I-Phenylbiguanide (PBG, 1%) and a 5HT3 receptor antagonist, 3-Tropanyl-indole-carboxylate methiodide (ICS-205,930) were applied topically to the rabbit eye, and intraocular pressure and pupil diameter were checked with a Tono-PenTM XL and a ruler.
RESULTS
Topical application of 1% PBG significantly increased IOP by 4.6+/-1.2 mmHg (p<0.001) over a period of up to 2 hours, the IOP maximum reached at 1 hour and caused pupil dilatation by 3.3+/-0.3mm (p<0.001) over a period of up to 5 hours, the dilation maximum reached at 2 hour. Topical preadministration of 1% ICS-205,930 prevented a rise in IOP but did not counteract on the pupil dilatation brought about by 5HT3 receptor agonist.
CONCLUSIONS
These findings indicate that topically applied 5HT3 receptor agonist could raise IOP and dilate pupil.

Keyword

I-Phenylbiguanide; ICS-205,930; Pupil diameter; Intraocular pressure

MeSH Terms

Dilatation
Intraocular Pressure*
Pupil*
Rabbits*