Penet rating Keratoplasty Results in 275 Cases

Ha, Dongwook; Kim, Chang Kook; Lee, Sang Eun; Sung, Kyung Rim; Tchah, Hungwon

Abstract

In this study we evaluated the risk factors that affect the survival rate of penetrating keratoplasty(PKP). Retrospectively we reviewed medical records of 275 cases which had taken PKP for 9 years between 1989 and 1997 in AMC. Mean age of patients was 39. 9 years and mean follow up period was 32.6 months. Only PKP was performed in 182 eyes(66%)and combined procedure with cataract extraction, silicon oil removal or glaucoma surgery in 93 eyes(34%). PKP was combined with cataract extraction and IOL insertion in 56 eyes. We analyzed the survival rate with Kaplan-Meier survival function. The survival rate was 94%for 3 months, 87%for 6 months, 78%for 1 year, 69%for 2 years, 62%for 5 years. According to the success rate based on etiology, keratoconus was highly successful in 82.6%and the survival rate of regraft or bullous keratopathy was significantly lower than that of keratoconus(p<0.01). Major cause of graft failure was rejection(68%)and rejection was occurred within 12 months following PKP in 65.2%. Rejection was reversed in 40.7%with medical treatment. So the factor that significantly affected the survival of graft was causative disease and this study suggested that the effort to prevent rejection was most important in graft survival.