J Korean Ophthalmol Soc.  1999 Apr;40(4):921-925.

Amiodarone Induced Keratopathy

• Heo JH
• Kim JY
• Kim CH

Abstract

Amidarone hydrochloride, benzofuran derivatives, particularly effective for the treatment of arrythmias by prolong the duration of the action potential in all cardiac-conducting tissues. We studied the 25 patients with typical amiodarone keratopathy, retrospectively. In 25 patients, ten patients developed grade 1, eleven patients developed grade 2, and four patients developed grade 3 keratopathy. They complained of decreased best corrected visual acuity(1 patient), halos(1 patient), hypothyroidism(3 patients), pulmonary toxicity(2 patients), thpatic dysfunction(5 patients) and sleep dusturbance(3 patients). Therefore ophthalmologists should be alert for the complications of amiodarone and regular careful slit-lamp examination will be helpful in minimizing amidarone toxicity.

Keyword

Amiodarone; Amiodarone keratopathy; Amiodarone toxicity

MeSH Terms

Action Potentials
Amiodarone*
Arrhythmias, Cardiac
Humans
Retrospective Studies
Amiodarone