J Korean Ophthalmol Soc.  1997 Mar;38(3):424-429.

Initial Mitomycin C Trabeculectomy in Young Patients

• Kim YY
• Jung HR

Abstract

Antimetabolites that inhibit postoperative fibroblast proliferation increases the success of glaucoma filtration surgery. However, the use of mitomycin C in young patients has not been extensively studied. The effectiveness of initialtrabeculectomy with mitomycin C or uncomplicated glaucoma in patients age 40 years or younger was evaluated in a consecutive series of 15 eyes of 10 patients. Thirteen eyes had juvenile primary open-angle glaucoma and 2 eyes had steroid induced glaucoma. Mitomycin C (0.002%) was applied for 2 to 4 minutes during the surgery. The success rate was evaluated with Kaplan-Meier analysis, and it was 78% at postoperative 9 months. Complications included postoperative hyphema(7 eyes), hypotony (2 eyes), and bleb-related endophthalmitis.

Keyword

Juvenile primary open-angle glaucoma; Mitomycin C; Trabe culectomy

MeSH Terms

Antimetabolites
Endophthalmitis
Fibroblasts
Filtering Surgery
Glaucoma
Glaucoma, Open-Angle
Humans
Kaplan-Meier Estimate
Mitomycin*
Trabeculectomy*
Antimetabolites
Mitomycin