J Korean Rheum Assoc.  2007 Dec;14(4):395-400.

Two Cases of Calcinosis Cutis Combined with Rheumatologic Disease

• Yi SW
• Lee SW
• Son MK
• Kim YJ
• Lee KH
• Kang EJ
• Choi ST
• Park MC
• Park YB
• Lee SK

Abstract

The calcinosis, dystrophic soft tissue calcification, occurs in damaged or devitalized tissues normal calcium/phosphorus metabolism. It is the subcutaneous tissues of connective tissues disease ?primarily systemic lupus erythematosus, scleroderma, or dermatomyositis - and may involve a relatively localized area. The calcinotic accumulations may result in muscle atrophy, joint contractures, and skin ulceration complicated by recurrent episodes of local inflammation and infection. Calcinosis may be the source of both pain and disability in connective tissue disease patients. While various therapeutic modality have been used, no treatment has convincingly prevented or reduced calcinosis. We report two cases of calcinosis cutis combined with rheumatic disease.

Keyword

Calcinosis cutis; Dystrophic calcification; Rheumatic disease

MeSH Terms

Calcinosis*
Connective Tissue
Connective Tissue Diseases
Contracture
Dermatomyositis
Humans
Inflammation
Joints
Lupus Erythematosus, Systemic
Metabolism
Muscular Atrophy
Rheumatic Diseases
Skin Ulcer
Subcutaneous Tissue

Figure

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  Fig. 1. Abdomen-pelvis CT at diagnosis, Case 1. There are extensive calcifications and fascial thickening involving left side abdominal wall, subcutaneous layer predominantly.

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  Fig. 2. Microscopic findings showing fat necrosis with calcification (H&E stain x 40) (A) and vacuolar interface dermatitis with necrotic keratinocytes (H&E stain∗200) (B). Case 1.

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  Fig. 3. Abdomen-pelvis CT showed extensive calcification involving gluteal area, subcutaneous layer predominantly. Case 2.

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