J Korean Rheum Assoc.  2007 Dec;14(4):375-378.

A Case of Wegener's Granulomatosis with Colitis

• Won HJ
• Han SH
• Park HK
• Ahn HS
• Lim HM
• Kim JY
• Choi WC

Abstract

Wegener's granulomatosis is an uncommon disease that is characterized by granulomatous necrotizing vasculitis affecting small vessels. It typically targets the upper and lower respiratory tract and the kidney, but gastrointestinal involvement is rare. A 41-year-old man who has been already diagnosed with Wegener's granulomatosis by nasal cavity biopsy was admitted with bloody diarrhea and high fever. He had discontinued taking the immunosuppressive medication. His colonoscopic finding revealed colitis and ulcer lesions which biopsies show vasculitis and ill-defined granuloma. Therefore he was treated with systemic steroid and improved dramatically.

Keyword

Wegener's granulomatosis; Colitis; Gastrointestinal

MeSH Terms

Adult
Biopsy
Colitis*
Diarrhea
Fever
Granuloma
Humans
Kidney
Nasal Cavity
Respiratory System
Ulcer
Vasculitis
Wegener Granulomatosis*

Figure

• 

  Fig. 1. There were several ulcerative lesions with peripheral mucosal edema and petechiae in the ileocecal valve (A) and colon (B).

• 

  Fig. 2. (A) Chronic vasculitis with intravascular neutrophilic thrombi (arrow) in lamina propria on the ileocecal valve (H&E stain x100). (B) Ulcer with ill-defined granulomas (arrows) on the colon (H&E stain x200).

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