J Korean Gastric Cancer Assoc.
2005 Jun;5(2):127-132.
Hepatoid Adenocarcinoma of the Stomach with Liver Metastasis
- Affiliations
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- 1Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. kulee@plaza.snu.ac.kr
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
- 3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- A hepatoid adenocarcinoma of stomach, a subtype of gastric cancr, is characterized by a histologic resemblance to a hepatocellular carcinoma and alpha-feto protein production. Another feature is early metastasis to the liver and lymph nodes, thus revealing a poor prognosis. We report a case of a hepatoid adenocarcinoma of the stomach with liver metastasis. A 52-year-old male visited our hospital with a chief complaint of indigestion. Gastroscopic examination showed a Borrmann type-II lesion on the lesser curvature of the antrum. The CT scan showed a suspected advanced gastric cancer with liver metastasis. The serum AFP level was 123 ng/ml. A radical subtotal gastrectomy and a right hemihepatectomy were performed simultaneously. Pathologic examination confirmed the lesion to be confined to the submucosa. The gastric lesion was a hepatoid adenocarcinoma, and the hepatic lesion was a metastatic adenocarcinoma from the stomach. Therefore, he was classified as having stage IV (T1N1M1) gastric cancer. In cases of a hepatoid adenocarcinoma of the stomach, even patients with early gastric cancer can be staged into the poor prognostic group.
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