J Korean Epilepsy Soc.  2001 Jun;5(1):65-69.

Safety and Efficacy of Topiramate Monotherapy in Children with Recent-onset Seizures

• Park WS
• Kim CW
• Park SP
• Kwon SH

Abstract

PURPOSE: To investigate the efficacy and safety of topiramate monotherapy in children with recent-onset seizures.
METHODS
An open-label, randomized, parallel group trial compared the efficacy and tolerability of topiramate monotherapy versus oxcarbazepine monotherapy in 54 children with newly diagnosed epilepsy.
RESULTS
Of the 54 patients treated with topiramate (N=25) or oxcarbazepine (N=29), 51 patients completed the full study period of 16 weeks. In topiramate group, 64% became seizure free, 20% demonstrated a greater than 50% degree in seizure frequency, and 4% got worsened in seizure frequency. In oxcarbazepine group, 59% became seizure free, 24% experienced a greater than 50% reduction in seizure frequency. The efficacy was not statistically different between the two groups. Adverse events were usually only mild to moderate and the tolerability of therapy was similar between the two groups.
CONCLUSION
Topiramate monotherapy was highly effective in controlling seizures of children with newly diagnosed epilepsy (seizure free rate : 64%).

Keyword

Topiramate monotherapy; Recent-onset seizures

MeSH Terms

Child*
Epilepsy
Humans
Seizures*