J Korean Soc Emerg Med.  2010 Jun;21(3):307-312.

Biochemical Markers (Multimarker Index) in the Diagnosis of Acute Cerebral Infarction with a Combination of Usability Tests: A Prospective Randomized Controlled Study

• Choi BH
• Park SH
• Jung W
• Park HK
• Kim MC
• Ko YG

Abstract

PURPOSE
We examined the utility of biochemical markers in the diagnosis of acute cerebral infarction and the relationship between panel results and the extent and severity of the infarct.
METHODS
Group-wise comparisons were made between a group (Group 1) consisting of 38 subjects who were shown through medical screening between April 2007 and March 2008 to have no past history of cerebral disorders and a group (Group 2) consisting of 55 subjects who had visited the ER (during the same period) within 24 hours after the onset of neurologic symptoms and who were diagnosed with stroke through magnetic resonance imaging. Tests were carried out using the Multimarker Index, which is based on the principle of immunofluorescence. B-type natriuretic peptide, D-dimer, matrix metalloproteinase-9, and S100beta were examined, and the Multimarker Index (MMX) was derived. The extent of the infarct lesion was assessed using a volumetry program.
RESULTS
The average MMX value was 2.27 in group I and 4.14 in group II, and the difference was statistically significant (p<0.05). For group II, the MMX value had a statistically significant correlation with both the extent of infarct lesion (r=0.46, p<0.001) and its severity (r=0.39, p<0.001).
CONCLUSION
We believe that biomarker tests using the MMX should provide useful data in diagnosing strokes, and be of utility in making decisions regarding additional diagnostic tests and early treatment.

Keyword

STROKE; Biologic marker; Fibrin fragment D; Brain natriuretic peptide

MeSH Terms

Biomarkers
Cerebral Infarction
Diagnostic Tests, Routine
Fibrin Fibrinogen Degradation Products
Fluorescent Antibody Technique
Magnetic Resonance Imaging
Mass Screening
Matrix Metalloproteinase 9
Natriuretic Peptide, Brain
Neurologic Manifestations
Prospective Studies
Stroke
Fibrin Fibrinogen Degradation Products
Matrix Metalloproteinase 9
Natriuretic Peptide, Brain