J Korean Diabetes Assoc.  2006 Nov;30(6):487-491.

Acquired Generalized Lipodystrophy with Severe Insulin Resistant Diabetes Mellitus

• Lee JM
• Sohn TS
• Son HS

Abstract

Acquired generalized lipodystrophy is a rare disease, and often follows autoimmune disease, prodromal infection, HIV infection. The clinical characteristics are generalized absence of fat, insulin resistance, diabetes mellitus, absence of ketosis, elevated basal metabolic rate, severe hypertriglyceridemia, and hepatomegaly. Here we experience and report a case of 16-year-old female patient who has clinical features of acquired generalized lipodystrophy with severe insulin resistant diabetes mellitus without any prodromal states.

Keyword

Diabetes mellitus; Hypertriglyceridemia; Lipodystrophy

MeSH Terms

Adolescent
Autoimmune Diseases
Basal Metabolism
Diabetes Mellitus*
Female
Hepatomegaly
HIV Infections
Humans
Hypertriglyceridemia
Insulin Resistance
Insulin*
Ketosis
Lipodystrophy
Lipodystrophy, Congenital Generalized*
Prodromal Symptoms
Rare Diseases
Insulin

Figure

• 

  Fig. 1 General appearance revealed a muscular hypertrophy, larger biacromial than bitrochanterian diameter, lack of subcutaneous fat on trunk and limbs, no development of breast.

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  Fig. 2 MRI of the liver. Hepatomegaly and fatty changes were detected.

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  Fig. 3 MRI of the thight. There ar no intramuscular fat deposit. But, bone marrow fat is preserved.

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