J Korean Diabetes Assoc.  2006 Nov;30(6):409-415.

Mitochondrial Dysfunction and Insulin Resistance

• Cho EH
• Koh EH
• Kim MS
• Park JY
• Lee KU

Abstract

No abstract available.

MeSH Terms

Insulin Resistance*
Insulin*
Insulin

Figure

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  Fig. 1 Interstitial glycerol concentration in (A) skeletal muscle and (B) adipose tissue under basal and hyperinsulinemic euglycemic clamp conditions, and (C) net change in the interstitial glycerol concentrations during clamp (D) interstitial ethanol concentrations in skletal muscle and adipose tissue during microdialysis12).

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  Fig. 2 AMPK in fatty acid oxidation and insulin resistance.

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  Fig. 3 Schematic model of the mechanism by which adiponectin synthesis is reduced in obesity. Adipocyte hypertrophy in obesity is associated with mitochondrial dysfunction, and consequent activation of iNOS and ER stress affect transcription and post-translational modification to result in decreased production of adiponectin.

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