J Korean Soc Emerg Med.  1998 Dec;9(4):614-621.

Developing of Systemic Inflammatory Response Syndrome and Serum TNF-alpha Level in Multiple Trauma Patients

• Kim H
• Lee KH
• Lim JC
• Cho JH
• Oh BJ
• Hwang SO

Abstract

BACKGROUND AND PURPOSE: The systemic inflammatory response syndrome(SIRS), as defied recently by critical-care specialists, may result from various etiologies including infection, bum, or trauma. The purpose of this study was to determine whether TNF- alpha is associated with the development of systemic inflammatory response syndrome caused by multiple trauma.
METHODS
The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study Multiple blood samples were serially drawn to measure seam TNF-alpha level on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-alpha was measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value far serum TNF-alpha.
RESULTS
Serum TNF-alpha. levels of SIRS group were persistency elevated above reference value until 3 days after on admission. Peak seam TNF-alpha level at 12 hours after admission was higher in SIRS group than non-SIRS group(p< 0.05). There was no significant correlation between injury severity score and TNF-alpha levels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16.
CONCLUSION
the result of this study suggests that persistent elevation of TNF-alpha and degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.

MeSH Terms

Emergency Service, Hospital
Enzyme-Linked Immunosorbent Assay
Humans
Injury Severity Score
Multiple Trauma*
Reference Values
Specialization
Systemic Inflammatory Response Syndrome*
Tumor Necrosis Factor-alpha*
Volunteers
Tumor Necrosis Factor-alpha