J Korean Soc Endocrinol.  2003 Apr;18(2):221-226.

A Case of Brown Tumor with Severe Hypercalcemia Caused by Parathyroid Adenoma

• Mok JO

Abstract

Most of primary hyperparathyroidism results from parathyroid adenoma, and is characterized by hypercalcemia, reduced bone density, frequent renal stone, gastric ulcer, duodenal ulcer, muscle weakness, depression, hypertension, anemia, and rarely brown tumor. We had a case of an 80-year-old man having brown tumor caused by primary hyperparathyroidism on the right 10th rib confirmed by CT guided bone biopsy. The patient presented with decreased level of consciousness, acute gastric ulcer, acute duodenal ulcer, GB stones, renal insufficiency, depression, and osteoporosis. Serum calcium level was 16.7 mg/dL and the intact parathyroid hormone level was 3901pg/mL. A parathyroid mass was detected by neck CT and 99mTc-tetrofosmin parathyroid scan. The parathyroid tumor was removed and confirmed as a parathyroid adenoma by pathology. After operation, the patient was treated with vitamin D and calcium in response to the resulting hungry bone syndrome. The intact PTH level returned to a normal range after the removal of the parathyroid adenoma.

MeSH Terms

Aged, 80 and over
Anemia
Biopsy
Bone Density
Calcium
Consciousness
Depression
Duodenal Ulcer
Humans
Hypercalcemia*
Hyperparathyroidism, Primary
Hypertension
Muscle Weakness
Neck
Osteoporosis
Parathyroid Hormone
Parathyroid Neoplasms*
Pathology
Reference Values
Renal Insufficiency
Ribs
Stomach Ulcer
Vitamin D
Calcium
Parathyroid Hormone
Vitamin D