J Lipid Atheroscler.  2016 Jun;5(1):79-86. 10.12997/jla.2016.5.1.79.

Quantitative Measurement of Effect of Short-term Life Style Modification on Lipid Profiles in Korean Patients with Hyperlipidemia

• Kim Y
• Jung M
• Kim CJ

• KMID: 2328840
• DOI: http://doi.org/10.12997/jla.2016.5.1.79

Abstract

OBJECTIVE
Effects of life style modifications on lipid profiles have been well established. However, data is scarce in Korean patients. We tried to quantify the effect of life style modifications on lipid profiles in relatively large number of Korean hyperlipidemic patients.
METHODS
This study enrolled 1037 consecutive hyperlipidemic patients (total cholesterol or triglyceride levels ≥200 mg/dL) from 2003 to 2013. They were consisted of patients with hypercholesterolemia (n=308), borderline hypercholesterolemia (n=302), mixed hyperlipidemia (n=107), borderline mixed hyperlipidemia (n=156), and hypertriglyceridemia (n=164). Blood lipid levels were measured before and after life style modification for 2-4 months.
RESULTS
Life style modification showed a small but significant reduction of body weight in all groups. It reduced low density lipoprotein (LDL) cholesterol by 9.1% (p=0.000), 5.9% (p=0.000), and 4.8% (p=0.003) in patients with hypercholesterolemia, borderline hypercholesterolemia, and mixed hyperlipidemia, respectively. LDL cholesterol was elevated in hypertriglyceridemic patients by 35% (p=0.000). Triglyceride levels decreased in patients with hypertriglyceridemia by 22% (p=0.000) and increased in hypercholesterolemic patients. There were no different effects of life style modification between men and women.
CONCLUSION
Life style modification made significant improvement in lipid profiles in Korean patients. The degree of improvement from this study may provide useful data for the management of Korean hyperlipidemic patients.

Keyword

Diet therapy; Life style; Hypercholesterolemia; Hypertriglyceridemia

MeSH Terms

Body Weight
Cholesterol
Cholesterol, LDL
Diet Therapy
Female
Humans
Hypercholesterolemia
Hyperlipidemias*
Hypertriglyceridemia
Life Style*
Lipoproteins
Male
Triglycerides
Cholesterol
Cholesterol, LDL
Lipoproteins

Figure

• 

  Fig. 1 Comparisons of Effects of Lifestyle Modification on Percent Changes of Lipid Profiles among Various Hyperlipidemia Groups. Mean±SE, HC; hypercholesterolemia, HL; mixed hyperlipidemia, HTG; hypertriglyceridemia, HDL-C; high density lipoprotein cholesterol, LDL-C; low-density lipoprotein cholesterol

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