Korean J Clin Neurophysiol.
2016 Jun;18(1):18-20. 10.14253/kjcn.2016.18.1.18.
Myelin Water Fraction MRI in a Case of Clinically Probable Amyotrophic Lateral Sclerosis
- Affiliations
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- 1Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea. dr.donghoon.shin@gmail.com
- 2Laboratory for Imaging Science and Technology (LIST), Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea.
- 3Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea.
- KMID: 2328824
- DOI: http://doi.org/10.14253/kjcn.2016.18.1.18
Abstract
- Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor neuron degeneration begins, and conflicting hypotheses have been suggested. Recent advanced radiological techniques enable us to look into ALS neuropathology in vivo. Herein, we report a case with upper motor neuron-predominant ALS in whom the results of brain magnetic resonance imaging (MRI) and myelin water fraction MRI suggest axonal degeneration.
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