J Korean Assoc Pediatr Surg.  2006 Dec;12(2):175-182.

The Experience of the VATER Association in One Hospital

Affiliations
  • 1Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. kimdy@amc.seoul.kr

Abstract

VATER association is defined as a combination of 3 or more anomalies- vertebra(V), imperforate anus (A), esophageal atresia with or without tracheoesophageal fistula (TE), renal and radial anomaly(R). We reviewed our experiences in one center to determine etiology, prevalence, clinical manifestation, other associated anomaly and prognosis. Two hundred and twenty-three cases that underwent operations for imperforate anus or esophageal atresia were analyzed retrospectively through medical records at Department of Pediatric Surgery, Asan Medical Center from June, 1989 to July, 2005. The total number of neonates who had been admitted during period of study were 46,773 and VATER association was 9 (0.019 %, 1.92 persons per 10,000 neonates). Median gestational age and birth weight were 37(+4)wk (35(+1) - 41(+4)) and 2,594 g (1,671-3,660), respectively and median age of mother was 32 years (23-38). There was no family history. Three patients were twins but their counterparts had no anomalies. Patients who have 3 anomalies were 6, 4 anomalies in two and 5 anomalies in one patient. Vertebra anomalies were detected in 7(77.7 %), imperforate anus in 8(88.9 %), esophageal atresia in 5 patients (55.6 %), renal anomaly in 6(66.7 %), and radial anomaly in 5(55.6 %), respectively. Four patients are alive, 2 patients were lost during follow up period. Three patients died due to neonatal sepsis, respiratory dysfunction and cardiac failure. VATER association did not appear to be a definite risk factor, but merely a randomized combination of 5 anomalies. The prognosis was dependent on the other associated anomalies, appropriateness of management and operation. Careful follow-up and aggressive treatmentare required for improving survival and quality of life.

Keyword

VATER association; VACTERL association; Esophageal atresia; Anorectal anomaly

MeSH Terms

Anus, Imperforate
Birth Weight
Chungcheongnam-do
Esophageal Atresia
Follow-Up Studies
Gestational Age
Heart Failure
Humans
Infant, Newborn
Medical Records
Mothers
Prevalence
Prognosis
Quality of Life
Retrospective Studies
Risk Factors
Sepsis
Spine
Tracheoesophageal Fistula
Twins
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