Ultrasonography.  2016 Jul;35(3):234-243. 10.14366/usg.15079.

Thyroid nodules with nondiagnostic results on repeat fine-needle aspiration biopsy: which nodules should be considered for repeat biopsy or surgery rather than follow-up?

• Eun NL
• Yoo MR
• Gweon HM
• Park AY
• Kim JA
• Youk JH
• Moon HJ
• Chang HS
• Son EJ

• KMID: 2327629
• DOI: http://doi.org/10.14366/usg.15079

Abstract

PURPOSE
The goal of this study was to assess the clinicopathologic and ultrasonographic features of thyroid nodules with nondiagnostic results on repeat ultrasonography (US)-guided fineneedle aspiration biopsy (FNAB) according to size and the number of suspicious findings and to determine the proper management of nodules with consecutive nondiagnostic results.
METHODS
This retrospective study included 297 nodules with nondiagnostic results on repeat FNAB that were evaluated by US over the course of at least 12 months of follow-up, a follow-up biopsy, or an operation. We compared clinical and US variables between benign and malignant nodules in thyroid nodules with repeat nondiagnostic results.
RESULTS
The comparison of benign and malignant nodules with repeat nondiagnostic results revealed that age, marked hypoechogenicity, irregular or microlobulated margins, microcalcifications, and nonparallel shape were significantly associated with malignancy. Multivariate logistic regression analysis in malignant nodules revealed that microcalcifications and irregular or microlobulated margins were independently associated with malignancy. Among them, only irregular or microlobulated margins were independently significant as a predictor of malignancy in repeatedly nondiagnostic nodules measuring >10 mm. Using receiver operating characteristic analysis, the best cutoff value for the "number of suspicious findings" between benign and malignant nodules was three in nodules of all sizes, three in nodules measuring ≤10 mm, and two in nodules measuring >10 mm.
CONCLUSION
Irregular or microlobulated margins may be the most frequent US features in repeatedly nondiagnostic nodules >10 mm. The presence of "two or more suspicious findings" can be used as the cutoff for distinguishing benign and malignant nodules.

Keyword

Biopsy, fine-needle; Thyroid nodule; Ultrasonography

MeSH Terms

Biopsy*
Biopsy, Fine-Needle*
Biopsy, Needle
Follow-Up Studies*
Logistic Models
Retrospective Studies
ROC Curve
Thyroid Gland*
Thyroid Nodule*
Ultrasonography