Ann Surg Treat Res.
2016 Jul;91(1):51-55. 10.4174/astr.2016.91.1.51.
Difficult diagnosis and localization of focal nesidioblastosis: clinical implications of â¶â¸Gallium-DOTA-D-Phe¹-Tyr³-octreotide PET scanning
- Affiliations
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- 1Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. jangjy4@snu.ac.kr
- 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2327417
- DOI: http://doi.org/10.4174/astr.2016.91.1.51
Abstract
- Focal nesidioblastosis is a rare cause of endogenous hyperinsulinemic hypoglycemia in adults. Because it is difficult to localize and detect with current imaging modalities, nesidioblastosis is challenging for biliary-pancreatic surgeons. â¶â¸Gallium-DOTA-D-Phe¹-Tyr³-octreotide PET scanning and ¹¹¹indium-pentetreotide diethylene triamine pentaacetic acid octreotide scanning may be superior to conventional imaging modalities in determining the localization of nesidioblastosis. We report the successful surgical treatment of a 54-year-old woman with focal hyperplasia of the islets of Langerhans, who experienced frequent hypoglycemic symptoms and underwent various diagnostic examinations with different results.
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