J Korean Acad Rehabil Med.
2009 Jun;33(3):316-320.
Relationship between Respiratory Muscle Strength and Cardiac Function in Duchenne Muscular Dystrophy
- Affiliations
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- 1Department of Rehabilitation Medicine and Rehabilitation Institute of Muscular Disease, Yonsei University College of Medicine, Korea.
- 2Department of Cardiology, Yonsei University College of Medicine, Korea.
- 3Department of Rehabilitation Medicine, College of Medicine, Cheju National University, Korea.
- 4Department of Physical Medicine and Rehabilitation, Myongji Hospital, Kwandong University College of Medicine, Korea. bettertomo@naver.com
Abstract
OBJECTIVE
To investigate the relationship between respiratory muscle strength and cardiac function in patients with Duchenne muscular dystrophy (DMD). METHOD: This study included 37 patients with DMD. Cardiac function of patients was evaluated by thoracic echocardiography, which recorded left ventricular ejection fraction (LVEF). Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) representing respiratory muscle strength and blood sampling for brain natriuretic peptide (BNP) were performed.
RESULTS
LVEF did not show significant correlation with MIP, MEP or age. However, LVEF was negatively correlated with BNP level.
CONCLUSION
Cardiac dysfunction of patients with DMD didn't correlate with age or respiratory muscle strength. Therefore, investigation of cardiac function itself is needed for patients with DMD irrespective of respiratory compromises.
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