J Korean Soc Ther Radiol Oncol.
2005 Mar;23(1):9-16.
Prediction of Prognosis to Concurrent Chemo-Radiotherapy by Standardized Uptake Value of 2-[18F] Fluoro-2-Deoxy-D-Glucose for Nasopharyngeal Carcinomas
- Affiliations
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- 1Departments of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. lsw@amc.seoul.kr
- 2Departments of Neclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 3Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 4Departments of Medical Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
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PURPOSE: To prospectively evaluate the use of positron emission tomography with the glucose analog fluorodeoxyglucose (FDG-PET) to predict disease-free survival (DFS) after concurrent chemo-radiotherapy (CCRT) in patients with non-disseminated nasopharyngeal carcinoma (NPC).
MATERIASL AND METHODS: We studied 41 patients with non-disseminated NPC scheduled to undergo platinum- based CCRT were eligible for this study. Patients were studied by FDG-PET prior to the CCRT. FDG uptake of tumors were measured with the maximal standardized uptake value (SUV).
RESULTS
Complete response rate was 100%. In ten patients who presented with any component of treatment failure, the median SUVmax was 8.55 (range: 2.49~14.81) in any component of failure and the median SUVmax was 6.48 (range: 2.31~26.07) in the remaining patients without any such failure. Patients having tumors with high FDG uptake had a significantly lower 3-year DFS (51% v 91%, P=0.0070) compared with patients having low uptake tumors.
CONCLUSION
FDG uptake, as measured by the SUV, has potential value in predicting DFS in NPC treated by CCRT. High FDG uptake may be a useful parameter for identifying patients requiring more aggressive treatment approaches.
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