J Korean Acad Rehabil Med.
2003 Apr;27(2):275-279.
The Resininferatoxin Therapy for the Hyperreflexive Neurogenic Bladder: Report of two cases of spinal cord injured patients
- Affiliations
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- 1Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Korea. serrom@hanmail.net
Abstract
- Resiniferatoxin, a substance isolated from some species of Euphorbia, a cactus-like plant, shows pharmacological effects similar to those of capsaicin. We administered resiniferatoxin for treating detrusor hyperreflexia to patient with chronic spinal cord injury. Resiniferatoxin solution (100 ml at a concentration of 10-7, 10-6 M) was instilled twice into the bladder of patient with detrusor hyperreflexia and left in place for 30 minutes. Effects on bladder function were monitored at 1 month later follow-up. One month after the last resiniferatoxin instillation, patients reported a significant symptomatic improvement of their incontinence and increased mean bladder capacity.
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