Korean J Urol.  1998 Jan;39(1):61-64.

The Effect of Desmopressin in Neurogenic Bladder due to Spinal Cord in Jury

• So JG
• Park WH
• Shim HB

Abstract

PURPOSE: Nocturia and enuresis are common voiding problems in spinal cord injured patients despite a variety of management. The purpose of this study is to determine the efficacy of desmopressin, a synthetic analogue of antidiuretic mono, as an alternative treatment in the management of spinal cord injured(SCI) patients with neurogenic bladder dysfunction unresponsive to conventional therapy.
MATERIALS AND METHODS
Fourteen SCI patients with nocturia or enuresis were included in this study. The patients received 10microgram desmopressin intranasally at bedtime once every 24 hours.
RESULTS
There was a significant decrease in nocturnal urinary volume, frequency of nocturia and nocturnal enuresis during nighttime after desmopressin administration. Two patients stopped desmopressin because of side effects. 8 of 12 patients improved with desmopressin and the remainder had no effect. There was no serum abnormality, although there were side effects in three cases, such as gastro-intestinal trouble, chest discomfort or nasal congestion.
CONCLUSIONS
Desmopressin is safe and effective in the management of nocturia or enuresis due to neurogenic bladder dysfunction in selected SCI patients.

Keyword

Desmopressin; Spinal cord injury; Neurogenic bladder

MeSH Terms

Deamino Arginine Vasopressin*
Enuresis
Estrogens, Conjugated (USP)
Humans
Nocturia
Nocturnal Enuresis
Spinal Cord Injuries
Spinal Cord*
Thorax
Urinary Bladder, Neurogenic*
Deamino Arginine Vasopressin
Estrogens, Conjugated (USP)