J Korean Soc Ther Radiol.  1991 Dec;9(2):215-220.

MVP Chemotherpy and Hyperfractionated Radiotherapy for Stage III Unresectable Non-Small Cell Lung Cancer: Randomized for maintenance Chemotherapy vs. Observation: Preliminary Report

• Choi EK
• Chang H
• Suh C
• Lee KH
• Lee JS
• Kim SH
• Choi CJ
• Koh YS
• Kim WS
• Kim WD
• Kim SH
• Sohn KH

Abstract

To evaluate the effect of MVP chemotherapy and hyperfractionated radiotherapy in Stage III unresectable non small cell lung cancer (NSCLC), authors have conducted a prospective randomized study since January 1991. Stage IIIa or IIIb unresectable NSCLC patients were treated with hyperfractionated radiotherapy (120 cGy/fx BID) up to 6500 cGY following 3 cycles of induction MVP (Mitomycin C 6 mg/m2, vinblastine 6 mg/m2, Cisplatin 60 mg/m2) and randomized for either oservation or 3 cycles of maintenance MVP chemotherapy. Until August 1991, 18 patients were registered to this study. 4 cases were stage IIIa and 14 were stage IIIb. Among 18 cases 2 were lost after 2 cycles of chemotherapy, and 16 were analyzed for this preliminary report. The response rate of induction chemotherapy was 62.5%; partial response, 50% and minimal response, 12.5%. Residual tumor of the one partial responder was completely disappeared after radiotherapy. Among 6 cases who were progressed during induction chemotherapy, 4 of them were also progressed after radiotherapy. All patients were tolerated BID radiotherapy without definite increase of acute complications, compared with conventional radiotherapy group. But at the time of this report, one patient expired in two month after the completion of the radiotherapy because of treatment related complication. Although the longer follow up is needed, authors are encouraged with higher response rate and acceptable toxicity of this treatment. Authors believe that this study is worthwhile to continue.

Keyword

NSCLC; MVP chemotherapy; Hyperfractionated radiotherapy

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Cisplatin
Drug Therapy
Follow-Up Studies
Humans
Induction Chemotherapy
Maintenance Chemotherapy*
Neoplasm, Residual
Prospective Studies
Radiotherapy*
Small Cell Lung Carcinoma
Vinblastine
Cisplatin
Vinblastine