Yeungnam Univ J Med.  1993 Dec;10(2):485-492.

Histopathologic findings of necrotizing lymphadenitis

• Shim YR
• Nam HJ

Abstract

Necrotizing lymphadenitis was first recognised as a self-limiting lymphadenitis by Japanese workers in 1972. It is a distinct clinicopathologic entity, but can be mistaken as malignant lymphoma. We have studied clinicopathologic features in 15 cases of necrotizing lymphadenitis. This disease occurs predominantly in young adult. Male-female ratio is 2 : 1. The commonest presentation is lateral cervical lymphadenopathy. Pain, tenderness, and fever can be seen. Biopsy of the lymph nodes from all patients demonstrates the characteristic histologic features : multifocal, relatively circumscribed nodules in the cortex and/or paracortex, consisting of a mixture of activated large lymphoid cells, histiocytes and Small lymphocytes. Numerous karyorrhetic debris are present. Neutrophils and plasma cells are strikingly absent.

MeSH Terms

Asian Continental Ancestry Group
Biopsy
Fever
Histiocytes
Humans
Lymph Nodes
Lymphadenitis*
Lymphatic Diseases
Lymphocytes
Lymphoma
Neutrophils
Plasma Cells
Young Adult