Yeungnam Univ J Med.  2011 Jun;28(1):54-59.

Rhabdomyolysis Induced Acute Kidney Injury in a Patient with Leptospirosis

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea. jwpark@med.yu.ac.kr
  • 2Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Republic of Korea.

Abstract

Leptospirosis is a spirochetal infectious disease caused by Leptospira interrogans, and may vary in degree from an asymptomatic infection to a severe and fatal illness. The kidney is one of the principal target organs of Leptospira. Renal disorders caused by Leptospira infection vary from an abnormality in urinalysis to acute kidney injury (AKI). Incidence of AKI in severe leptospirosis varies from 40% to 60%. AKI reflects the severity of leptospirosis and is generally accompanied by cholestatic jaundice. The pathophysiology of AKI in leptospirosis consists of hypovolemia, direct tubular toxicity, and rhabdomyolysis. Most patients with acute leptospirosis experience severe myalgias, and show laboratory evidence of mild rhabdomyolysis. However, occurrence of severe rhabdomyolysis is rare. We report here on a patient with leoptospirosis, who had severe rhabdomyolysis and acute kidney injury without jaundice.

Keyword

Leptospirosis; Acute renal failure; Rhabdomyolysis

MeSH Terms

Acute Kidney Injury
Asymptomatic Infections
Communicable Diseases
Humans
Hypovolemia
Incidence
Jaundice
Jaundice, Obstructive
Kidney
Leptospira
Leptospira interrogans
Leptospirosis
Rhabdomyolysis
Urinalysis
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