Yeungnam Univ J Med.
2011 Dec;28(2):173-179.
Development of Steroid Myopathy during Polymyositis Treatment
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Department of Physical Medicine and Rehabilitation, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
- 3Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.
- 4Department of Internal Medicine, Division of Rheumatology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. chanheell@paran.com
Abstract
- Polymyositis is diffuse, inflammatory myopathy with proximal-muscle weakness due to lymphocyte infiltration to the muscle layer. The exact cause of the muscle weakness is unclear but may be related with an immunologic mechanism. Using high-dose steroid is the treatment of choice for polymyositis. It is difficult to distinguish steroid-resistant polymyositis from steroid myopathy, however, in the course of high-dose steroid therapy. These authors encountered a steroid myopathy patient during polymyositis treatment with high-dose steroid. A 57-year-old woman was diagnosed with polymyositis and was treated with high-dose steroid. Her condition was initially improved, but in the course of the treatment, her symptom was aggravated without increasing the muscle enzymes. Her muscle weakness was improved by reducing the steroid dosage.
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