Yeungnam Univ J Med.  2013 Dec;30(2):152-155.

A Case of Metastatic Hepatocellular Carcinoma of the Orbit

• Yang YJ
• Bae SH
• Jang IY
• Jun MJ
• Jung JW
• An JH
• Shim JH

Abstract

Orbital metastasis from hepatocellular carcinoma is very rare, with only 14 biopsy-proven cases from hepa tocellular carcinoma cases reported in English literature and three cases reported in Korea. Common symptoms of orbital metastasis are proptosis, visual loss, ocular pain and oculomotor dysfunction. For its precise diagnosis, we can perform fine needle aspiration biopsy, orbit CT or MRI, and ultrasonography. Radiotherapy is the mainstay in the treatment of orbital metastasis. In addition, chemotherapy, hormonal therapy and surgical intervention can play a role in the treatment of orbital metastasis according to the primary cancer and symptoms. However, the prognosis of orbital metastasis is poor. We report herein a rare case of a patient with orbital metastasis from hepatocellular carcinoma, which was treated with various modalities that included resection, and who had good clinical and radiological responses to radiation therapy and sorafenib (Nexavar, Bayer HealthCare).

Keyword

Eye neoplasm; Hepatocellular carcinoma; Metastasis; Radiotherapy; Sorafenib

MeSH Terms

Biopsy
Biopsy, Fine-Needle
Carcinoma, Hepatocellular*
Diagnosis
Drug Therapy
Exophthalmos
Eye Neoplasms
Humans
Korea
Magnetic Resonance Imaging
Neoplasm Metastasis
Orbit*
Prognosis
Radiotherapy
Ultrasonography