Tuberc Respir Dis.  2011 Oct;71(4):282-285.

A Case of Common Variable Immune Deficiency Presenting as Recurrent Pneumococcal Pneumonia

• Jeong J
• Cho JH
• Nam H
• Ryu JS
• Kwak SM
• Lee HL

Abstract

Common variable immune deficiency (CVID) is the most common primary immune deficiency, which is manifested as chronic recurrent respiratory infections and hypoglobulinemia. CVID usually presents in the second or third decade of life. A 33-year-old woman was admitted with recurrent pneumococcal pneumonia with bacteremia and had very low levels of serum immunoglobulin G, M and A. This case emphasized a high index of suspiciousness for diagnosis of CVID in a mid-adulthood patient presenting with recurrent pneumonia with hypoglobulinemia.

Keyword

Common Variable Immunodeficiency; Pneumonia, Pneumococcal; B-Lymphocytes

MeSH Terms

Adult
B-Lymphocytes
Bacteremia
Common Variable Immunodeficiency
Female
Humans
Immunoglobulin G
Pneumonia
Pneumonia, Pneumococcal
Respiratory Tract Infections
Immunoglobulin G

Figure

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  Figure 1 (A) Chest x-ray at previous admission showed pneumonia in right upper, lower lung and left lower lung field. (B) Chest x-ray at this admission demonstrated recurrence of pneumonia in right upper lung field.

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  Figure 2 Serum electrophoresis showed a markedly decreased gamma globulin fraction.

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  Figure 3 Chest CT scan showed right paratracheal lymph nodes enlargements and parenchymal infiltrates on right upper lobe. CT: computed tomography.

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