Urogenit Tract Infect.  2015 Oct;10(2):84-91. 10.14777/uti.2015.10.2.84.

Management of Extended-Spectrum Beta-Lactamase-Positive Gram-Negative Bacterial Urologic Infections

• Lim YK
• Lee MK
• Kim TH

• KMID: 2319432
• DOI: http://doi.org/10.14777/uti.2015.10.2.84

Abstract

Extended-spectrum beta-lactamases (ESBLs) are enzymes that confer increased resistance to commonly used antibiotics. The prevalence rates of ESBL producing bacteria are increasing, and the associated increase in morbidity and mortality is becoming a public health concern. ESBL producers are emerging as an important cause of urinary tract infection (UTI) and empirical therapy should therefore be carefully selected for patients with UTI. Fosfomycin or nitrofurantoin would be an appropriate choice for empirical therapy of uncomplicated UTI. Ertapenem or cefepime might be recommended for initial empirical therapy patients suspected of having complicated UTI.

Keyword

Extended-spectrum beta-lactamases; Urinary tract infections; Antibacterial agents

MeSH Terms

Anti-Bacterial Agents
Bacteria
beta-Lactamases
Fosfomycin
Humans
Mortality
Nitrofurantoin
Prevalence
Public Health
Urinary Tract Infections
Anti-Bacterial Agents
Fosfomycin
Nitrofurantoin
beta-Lactamases

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