Tuberc Respir Dis.  2010 Jan;68(1):10-15.

Cell Differentiation Might Predict the Recurrence in Surgically Resected Non-Small Cell Lung Carcinoma

• Kang HK
• Cho SG
• Lee HM
• Park SW
• Lee BO
• Lee JH
• Kim BM
• Park IW

Abstract

BACKGROUND
Lung cancer is the most common cause of cancer mortality in Korea. The TNM stage at presentation in patients with non-small cell lung cancer (NSCLC) has the greatest impact on prognosis. Patients who undergo a complete resection for NSCLC are likely to develop recurrent and/or metastatic disease. There are several factors influencing the development of recurrence. We explored risk factors of recurrence in patients with stages I and II NSCLC, who had undergone curative resection.
METHODS
We reviewed patients who had complete surgical resection as definitive treatment for stage I or II. Patients followed up for more than 36 months. We evaluated several factors which might have relationship with recurrence, such as patient's demographic factors, TNM staging, pathologic finding, tumor markers and surgical technique.
RESULTS
A total of 75 patients were enrolled for analysis, of whom 58 were men and 17 were women with mean age of 61 (range, 37 to 76) years. The average size of tumors was 3.9 cm (0.7 to 10 cm). There were 64 patients with stage I NSCLC and 11 with stage II NSCLC. Among 64 patients with stage I NSCLC, 35 patients showed recurrences whereas 8 patients have recurred in stage II NSCLC. Grade of differentiation of tumor was closely related to the recurrence. Seventy-five percent of patients who had poor tumor differentiation experienced a recurrence. In contrast, 3 patients of twelve had recurrences, who revealed differentiation in their tissue (p<0.05).
CONCLUSION
Tumor differentiation could be a predictive factor for tumor recurrence in patients who have undergone curative resection for stage I or II NSCLC.

Keyword

Carcinoma, Non-Small-Cell Lung; Recurrence; Risk Factors; Cell Differentiation

MeSH Terms

Carcinoma, Non-Small-Cell Lung
Cell Differentiation
Demography
Female
Humans
Korea
Lung
Lung Neoplasms
Male
Neoplasm Staging
Prognosis
Recurrence
Risk Factors
Biomarkers, Tumor

Figure

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  Figure 1 Patient population enrolled and excluded in this study.

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  Figure 2 Recurrence rate of patients with stage I, II stratified by differentiation.

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  Figure 3 The Kaplan-Meier survival curves in patients with stage I, II non-small cell lung cancer stratified by histologic grades.

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