Tuberc Respir Dis.  2008 Oct;65(4):301-307.

Prognostic Utility of the Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Patients with Acute Respiratory Distress Syndrome

• Huh JW
• Jung H
• Lim CM
• Koh Y
• Hong SB

Abstract

BACKGROUND: The triggering receptor expressed on myeloid cells-1 (TREM-1) is an activating receptor that is expressed on the surface of neutrophils and mature monocytes when stimulated with several microbial components, which can amplify the inflammatory response. This study analyzed the prognostic value of the sTREM-1 levels in patients with acute respiratory distress syndrome (ARDS).
METHODS
The bronchoalveolar lavage (BAL) fluid and blood was collected prospectively from 32 patients with ARDS, 15 survivors and 17 nonsurvivors. An enzyme-linked immunosorbent assay was performed to measure the sTREM-1. The following data was obtained: APACHE II score, Clinical Pulmonary Infection Score (CPIS), BAL fluid analysis, C-reative protein. Mortality in the ICU was defined as the end point.
RESULTS
The serum sTREM-1 level was significantly higher in the nonsurvivors than survivors (54.3+/-10.3 pg/ml vs. 22.7+/-2.3 pg/ml, p<0.05). The sTREM-1 level in the serum, but not in the BAL fluid, was an independent predictor of the ICU mortality (OR: 22.051, 95% CI: 1.780~273.148, p<0.016), and a cut-off value of > or =33 pg/ml yielded a diagnostic sensitivity of 71% and specificity of 93%.
CONCLUSION
The serum sTREM-1 level may be a useful predictor of the outcome of ARDS patients.

Keyword

Acute respiratory distress syndrome; Triggering receptor expressed on myeloid cells-1; Prognosis; Mortality

MeSH Terms

APACHE
Bronchoalveolar Lavage
Enzyme-Linked Immunosorbent Assay
Humans
Monocytes
Neutrophils
Prognosis
Prospective Studies
Respiratory Distress Syndrome, Adult
Survivors

Figure

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  Figure 1 Concentration of sTREM-1 in BAL fluid and serum of patients with ARDS. (A) All patients. (B) Pulmonary ARDS.

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  Figure 2 Receiver operating characteristics curve for cut-off levels of soluble triggering receptor expressed on myeloid cells (sTREM-1) for prognostic factor. Areas under the ROC curve were 0.776 (95% CI, 0.606-0.947, p<0.05) for serum sTREM-1.

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