Tuberc Respir Dis.  2006 Oct;61(4):384-388.

A Case of Goodpasture's Syndrome Combined with Crohn's Disease

• Kim JY
• Bae JY
• Jung EJ
• Kim YK
• Lee YM
• Kim KU
• Uh ST
• Hwang JH
• Jin SY
• Lee DW

Abstract

A 29-year-old male patient was admitted due to his general weakness and poor oral intake for several months. He was diagnosed as having Crohn disease 16 years ago and total colectomy was performed 10 years ago. On the 3rd day after admission, gross hematuria and sudden hemoptysis combined with diffuse infiltration were noted on chest X-ray. His symptoms and the diffusely increased lung opacities improved with administering high-dose steroid therapy. Later, anti-GBM antibody was found to be positive on the laboratory findings. We report here on a rare case of Goodpsture syndrome combined with prolonged Crohn disease along with a review of literature.

Keyword

Goodpsture syndrome; Crohn disease; anti-GBM antibody

MeSH Terms

Adult
Anti-Glomerular Basement Membrane Disease*
Colectomy
Crohn Disease*
Hematuria
Hemoptysis
Humans
Lung
Male
Thorax

Figure

• 

  Figure 1 Surgical specimen of intestine. Multiple cobble stone and longitudinal ulcers are noted, and also skip areas locate between ulcer (arrow).

• 

  Figure 2 Histologic finding of intestine. Lymphoid hyperplasia and multiple non-caseating granulomas are shown.

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  Figure 3 Serial follow up of chest X-ray. A: At admission, diffuse hazy infiltration was noted on right lung field. B: Two days after admission, more aggravated and newly developed haziness wereas noted on right and left lung fields, respectively. C: Seven days after admission, increased haziness wereas still noted on both lung fields. D: 18 days after admission, haziness slightly improved with steroid therapy.

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